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3 hours ago Ncbi.nlm.nih.gov Show details
Box 1. The cyclin family. Cyclins are a large family of approximately 30 proteins varying in mass from 35 to 90 kDa. These proteins are structurally defined by the presence of the so-called cyclin box, a domain of approximately 100 amino acid residues that forms a stack of five α-helices.
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8 hours ago Uniprot.org Show details
Cyclin B Imported Gene names i: Name: Belongs to the cyclin family. UniRule annotation. Family and domain databases. CDD i: cd00043, CYCLIN, 2 hits InterPro i: View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671
7 hours ago Sciencedirect.com Show details
As cells proceed through G2, cyclin A is degraded by a ubiquitin-mediated proteolytic mechanism at the same time that cyclin B is actively synthesized. During mid-to-late G2, cyclin B/CDK1 complexes form and play multiple essential roles during the G2/M transition and during the progression of cells through mitosis (see Fig. 10–3 ).
3 hours ago Genomebiology.biomedcentral.com Show details
Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of …
8 hours ago En.wikipedia.org Show details
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present). The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting factor (MPF).
8 hours ago Researchgate.net Show details
activity of a Chinese Medicinal recipe, Dangg ui Longhui. family (reviewed in Cooksey, 2001), (3) urine of healthy. two protein kinases, CDK1/cyclin B and GSK-3
Category: Healthy Recipes, Chinese RecipesShow Details
In addition, indirubins constitute the first family of low nanomolar inhibitors of GSK-3β to be described (Leclerc et al., 2001). Upon testing a series of indoles and bis-indoles against GSK-3β, CDK1/cyclin B and CDK5/p25, only indirubins were found to inhibit these kinases (Leclerc et al., 2001).
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2 hours ago Mct.aacrjournals.org Show details
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines Chafiq Hamdouchi,1 Heather Keyser,1 Elizabeth Collins,1 Carlos Jaramillo,2 Jose Eugenio De Diego,2 Charles D. Spencer,1 Jack Alan Dempsey,1 Bryan D. Anderson,1 Tillie Leggett,1 Nancy B. Stamm,1 Richard M. Schultz,1 Scott A. Watkins,1 Kim Cocke,1 Stephanie Lemke,1 Teresa F. Burke,1
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3 hours ago Eurekaselect.com Show details
Abstract: Background: Cyclin-dependent kinase 2 (CDK2) has been studied due to its role in the cell-cycle progression. The elucidation of the CDK2 structure paved the way to investigate the molecular basis for inhibition of this enzyme, with the coordinated …
5 hours ago Researchgate.net Show details
While screening for inhibitors of cyclin-dependent kinases (CDK's) and glycogen synthase kinase-3 (GSK-3), we identified pyrazolo[3,4-b]quinoxalines as sub-micromolar inhibitors of CDK1/cyclin B.
5 hours ago Biocrick.com Show details
Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
Just Now Panaxea.com Show details
• Kong, M., et al., Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. Embo J, 2000. 19(6): p. 1378-88. • Kreis, W., D.R. Budman, and A. Calabro, Unique synergism or antagonism of combinations of chemotherapeutic and hormonal agents in human prostate cancer cell lines.
2. Cyclin-Dependent Kinases (CDKs) There are 20 members of CDK family known to this day regulating the cell cycle, transcription and splicing. The kinases are organized in a pathway to ensure that, during cell division, each cell accurately replicates its DNA, and ensures its segregation equally between the two daughter cells .Deregulation of any of the stages of the cell cycle or
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9 hours ago Tryl2012.blogspot.com Show details
Aqueous extract from Pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice
2 hours ago Thebiologist.rsb.org.uk Show details
B iochemistry is sometimes compared to cookery. Chefs and biochemists both mix ingredients and wait with excited expectation for the result – either a delicious new dish or an experimental outcome. They both follow recipes, although biochemists refer hope this one-off biochemistry special whets your to theirs as ‘experimental protocols’.
3 hours ago Cell.com Show details
We are working on a model of human immunodeficiency virus 1 (HIV-1)-induced cell death based on multinuclear giant cells or ‘syncytia’, which allow cell death to be studied at a higher level of spatial resolution than can be achieved with normal (uninuclear) cells. The fusion of somatic cells resulting in the formation of syncytia is a normal developmental process, but nonphysiological
1 hours ago Bmcecolevol.biomedcentral.com Show details
Duplication of cyclin B genes and formation of paralogs (CLB3-4; CLB1-2 and CLB5-6) was characteristic of some of the fungal taxa (Saccharomycotina); as for the other taxa, their salient feature was the presence in the genome of just one representative homolog of the cyclin B family, cdc13 (Ascomycetes, Pezizomycotina, the sole representative
Just Now Uniprot.org Show details
View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N: PANTHER i: PTHR10177, PTHR10177, 1 hit: Pfam i: View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit: PIRSF i: PIRSF001771, Cyclin_A_B_D_E, 1 hit: SMART i
Just Now Nature.com Show details
Cyclin-dependent kinase (CDK) 9 associates mainly with cyclin T1 and forms the positive transcription elongation factor b (p-TEFb) complex responsible for …
9 hours ago Repositori.udl.cat Show details
Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ingredient of a Traditional Chinese Medicinal recipe used against chronic myelocytic leukemia. Numerous indirubin analogs
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3 hours ago Jbc.org Show details
recipe used in the treatment of chronic diseases such as (CDKs)1 (25), a family of key cell cycle regulators (26–28). Indirubins act by competing with ATP for binding to the catalytic site of the kinase. The the levels of cyclin D1 (30) and b-catenin (31), dorsal-ventral patterning during development (31–33), insulin action on gly-
3 hours ago Turmericforhealth.com Show details
Curcumin acts specifically on both these proteins especially cyclin B and D. This helps in interrupting the cell cycle of cancer cells. 2. Cyclin dependant kinase inhibitors (Cip/Kip family) As the name suggests these proteins inhibit the activity of cyclin and cyclin dependant kinases and …
5 hours ago Kylejnorton.blogspot.com Show details
Caspase-8.(6) or through G2/M phase arrest was also associated with decreases in the amounts of cyclin B, cyclin A, cdc2, and cdc25C, and increases in the …
3 hours ago Abcam.com Show details
Cell Biology Cell Cycle Cyclins Cyclin B Family. Share by email Anti-Cyclin B2/CCNB2 antibody [X29.2] (ab18250) Datasheet; Reviews (3) I think one of those options will work for you. Here is my recipe for the TBST buffer: • TBS 10x (concentrated TBS) -24.23g Trizma HCl -80.06g NaCl Mix in 800ml ultra pure water. pH to 7.6 with pure HCl.
1 hours ago Biomol.com Show details
Buy CDK1 PrEST Antigen, item number: ATA-APrEST86431.100 from Atlas Antibodies at Biomol!
1 hours ago Pubmed.ncbi.nlm.nih.gov Show details
Testing of a series of indoles and bis-indoles against GSK-3 beta, CDK1/cyclin B, and CDK5/p25 shows that only indirubins inhibit these kinases. The structure-activity relationship study also suggests that indirubins bind to GSK-3 beta's ATP binding pocket in a way similar to their binding to CDKs, the details of which were recently revealed by
2 hours ago Giachinoplasticsurgery.com Show details
The main kinase that controls cell division is Cyclin B-CDK1. A team of researchers, led by Dr. Adrian Saurin at the University’s School of Medicine, have uncovered an entirely new function for this kinase that, surprisingly, does not depend on its kinase activity.
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4 hours ago Heartsinhealthcare.com Show details
The Happy Easy Keto Recipes. Is the keto diet for you? Max Mind Lean Body The Over 40 Solution. The Most Effective Weight Loss Diet. Flat Belly Transformation. Lose Belly Fat Exercises. Fitness (current) Quit Smoking Magic. Want to quit smoking. How To Bolster Your Immune System. Immune System Boosters
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8 hours ago Jbc.org Show details
The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the treatment of chronic diseases such as leukemias. The antitumoral properties of indirubin appear to correlate with their antimitotic effects. Indirubins were recently described as potent (IC50: 50–100 nm) inhibitors of cyclin-dependent kinases (CDKs).
5 hours ago Bidom.99readbesttop.info Show details
Identification Of Cyk, A Cyclin B2 Kinase As A Novel Calcium, Calmodulin Dependent Protein Kinase II And Its Role During Xenopus Laevis Oocyte (Acta Biomedica Lovaniensia, 205)Ilse Stevens, Global Issues In Employment Discrimination LawBrian Landsberg, The Peep Of Day: A Family Devotional Guide To The BibleF. L. Mortimer, Capitular Masonry Or The Royal Arch ChapterHenry Ridgley Evans
9 hours ago Link.springer.com Show details
· Uncontrolled proliferation and cell growth is the hallmark of many different malignant diseases, including sarcomas. Cyclin-dependent kinases (CDKs) are members of the serine/threonine protein kinase family and play crucial roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA splicing. In addition, several CDKs influence multiple …
2 hours ago Geneticengineeringinfo.blogspot.com Show details
When the cell is ready to transition into the next phase, CDKCs, cyclin D1-Cdk4 and cyclin D1-Cdk6 phosphorylate pRB, followed by additional phosphorylation from the cyclin E-Cdk2 CDKC. Once phosphorylation occurs, transcription factors are then released to irreversibly inactivate pRB and progression into the S phase of the cell cycle ensues.
Just Now Europepmc.org Show details
A B-type cyclin-independent oscillator may drive G1 events (Haase and Reed, 1999; Orlando et al., 2008). To determine if this oscillator might also drive Cdc14 endocycles, we overexpressed the stable Clb-Cdk inhibitor Sic1-4A to inhibit all B-type cyclin-Cdk activity (Verma et al., 1997).
6 hours ago Bosterbio.com Show details
EZH2 phosphorylation promotes H3K27me3 upkeep and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration through peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).
2 hours ago Mussenhealth.us Show details
First, the cyclin B protein is expressed uniquely at the end of the S phase and during the M phase, being rapidly degraded as cells enter the next G1 phase.102 Second, Cdk1 (also known as Cdc2) kinase activity is tightly regulated by an antagonistic posttranslation modification: phosphorylation by the Wee1 and myt1 kinases103 and
8 hours ago Biomol.com Show details
Buy CDK2 protein-GST fusion, item number: 009-001-R63 from Rockland Immunochemicals at Biomol!
8 hours ago Theplus-health.blogspot.com Show details
Caspase-8.(6) or through G2/M phase arrest was also associated with decreases in the amounts of cyclin B, cyclin A, cdc2, and cdc25C, and increases in the phosphorylation of …
4 hours ago Bosterbio.com Show details
For more info on STX8, check out the STX8 Infographic We have 30,000+ of these available, one for each gene! check them out. In this infographic you will see the following information for STX8: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases
7 hours ago Lookformedical.com Show details
The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE. G2 Phase. The period of the CELL CYCLE following DNA synthesis (S PHASE) and preceding M PHASE (cell division phase). The CHROMOSOMES are tetraploid in this point. S Phase Cell Cycle Checkpoints.
Just Now Tryl2012.blogspot.com Show details
BBR Inhibits the Proliferation and Induces Cell Cycle Arrest in UtLM Cells. BBR treatment significantly reduced UtLM cell viability in a dose-dependent manner ( Fig. 2 A and 1B) and inhibited UtLM cell growth by approximately 34%, 66%, and 67% at concentrations of 10, 20, and 50 μM, respectively. BBR treatment also significantly inhibited the
Alpinia pricei has been shown to induce apoptosis in human squamous carcinoma (KB) cells. In this study, we report the effectiveness of the ethanol (70%) extracts of A. pricei rhizome (AP extracts) in terms of tumor regression as determined using both in vitro cell culture and in vivo athymic nude mice models of KB cells. We found that the AP extract (25–200 μg/mL) treatment decreased the
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4 hours ago Deepdyve.com Show details
BSTCR might exert its beneficial role in oocyte maturation and restore DOR through regulating the BDNF pathway. And this pathway itself is probably through the consequence on several serum hormones such as FSH, E2, Inhibin B, etc.
9 hours ago Bmcbiochem.biomedcentral.com Show details
Lamins A and C, two major structural components of the nuclear lamina that determine nuclear shape and size, are phosphoproteins. Phosphorylation of lamin A/C is cell cycle-dependent and is involved in regulating the assembly–disassembly of lamin filaments during mitosis. We previously reported that P-STM, a phosphoepitope-specific antibody raised against the autophosphorylation site …
3 hours ago Go.drugbank.com Show details
Matched Polypeptides name: … Cyclin-dependent kinase 1 … Matched Polypeptides specific function: … Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which …
3 hours ago Ovarianresearch.biomedcentral.com Show details
Sulforaphane (SFN) is an extract from the mustard family recognized for its anti-oxidation abilities, phase 2 enzyme induction, and anti-tumor activity. This study investigated the cell cycle arrest in G2/M by SFN and the expression of cyclin B1, Cdc2, and the cyclin B1/CDC2 complex in PA-1 cells using western blotting and co-IP western blotting.
Because cyclin B is necessary for cells to enter mitosis and therefore necessary for cell division, cyclin B levels are often de-regulated in tumors. When cyclin B levels are elevated, cells can enter M phase prematurely and strict control over cell division is lost, which is a favorable condition for cancer development.
Twenty nine cyclins sharing the cyclin box belong to group of proteins that are present in cells during the cell proliferation . Their name derives from the fact that their concentration varies cyclically during the cell cycle; their synthesis and degradation depends on the different stages of the mitotic cell division cycle .
In order for the cell to progress out of mitosis, the degradation of cyclin B is necessary. The cyclin B/CDK1 complex also interacts with a variety of other key proteins and pathways which regulate cell growth and progression of mitosis. Cross-talk between many of these pathways links cyclin B levels indirectly to induction of apoptosis.
It has also been observed that decreasing cyclin B levels in cells increases the levels of functional p53. Therefore, siRNAs for cyclin B may be an effective treatment against cancers where p53 function is inhibited but the gene has not been deleted.